- Expression and Prognostic Significance of Serum Response Factor in Cholangiocarcinoma.
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Shin Young Park, Kyu Yun Jang, Yo Na Kim, Hee Jin Kim, Ho Sung Park, Myoung Ja Chung, Hee Chul Yu, Baik Hwan Cho, Kyoung Ryul Kim, Woo Sung Moon
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Korean J Pathol. 2009;43(6):517-522.
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DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.517
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 Abstract
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- BACKGROUND
Serum response factor (SRF) is a transcriptional factor that plays an important role in cell growth and differentiation for several types of cells. The expression of SRF in cholangiocarcinoma (CC) and its potential role has not been examined. The aim of this study was to determine the relationship between the expression of SRF in CC and the clinicopathological parameters, as well as patient survival.
METHODS
We analyzed the expression of SRF in 84 surgically resected cases of CC (33 cases of intrahepatic CC [ICC] and 51 cases of extrahepatic CC [ECC]) by using immunohistochemistry. RESULTS: The positive expression of SRF was detected in 48.8% of the cases of CC (42.4% in ICC, 52.9% in ECC). SRF was predominantly expressed in the CC cells with intense labeling in the nucleus. A SRF expression was significantly associated with the cell proliferation rate (Ki-67 labeling index, p=0.046) and poor patient survival (p=0.002). The tumor differentiation (p=0.038), the T category (p<0.001), lymph node and distant metastasis (p<0.001, p=0.009) and nerve and vessel invasion (p=0.010, p=0.012) were also found to be significantly associated with a poor CC prognosis. CONCLUSIONS: These results suggest that the SRF may play a role in the tumor cell proliferation of CC, and its expression in tumor cells can provide additional prognostic information.
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Citations
Citations to this article as recorded by  - Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma
JUN SANG BAE, SANG JAE NOH, KYOUNG MIN KIM, KYU YUN JANG, MYOUNG JA CHUNG, DAE GOHN KIM, WOO SUNG MOON
International Journal of Oncology.2014; 44(1): 129. CrossRef - Clinicopathologic significance of serum response factor expression in colorectal adenocarcinomas
Se Min Jang, Young Jin Jun, Hulin Han, Kang Hong Lee, Ki-Seok Jang, Seung Sam Paik
Basic and Applied Pathology.2011; 4(2): 46. CrossRef
- Enhanced CD24 Expression in Colorectal Cancer Correlates with Prognostic Factors.
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Yoon La Choi, Hua Xuan Yan, Sang Jeon Lee, Seon Mee Park, Wun Jae Kim, Hee Jin Kim, Seok Hyung Kim
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Korean J Pathol. 2006;40(2):103-111.
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Abstract
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- BACKGROUND
CD24 was originally described as a B cell-specific marker, however its aberrant expression in various solid tumors has recently been reported. Our objective was to determine the pattern and extent of the CD24 expression in colorectal cancer and its related lesions, and to clarify its correlation with clinico-pathological parameters and especially those associated with patients' prognoses.
METHODS
A total of 307 colorectal cancers and the related lesions (150 carcinomas, 30 high-grade adenomas, 49 low-grade adenomas, 41 hyperplastic polyps, and 37 normal colorectal epithelia) were immunohistochemically analyzed by treating CD24 monoclonal antibody onto tissue embedded paraffin blocks.
RESULTS
CD24 expression was very rarely observed in the normal epithelia, hyperplastic polyps, and low-grade adenomas; however, in high-grade adenomas, the CD24 expression was shown to be mildly increased in the cytoplasm (13.3%). In carcinomas, the CD24 expression was increased substantially in both the membrane (38.0%) and the cytoplasm (44.7%). The expression of CD24 in the membrane was positively correlated with tumor size (p<0.01). The CD24 expression in the cytoplasm was positively correlated with several unfavorable parameters, including a larger tumor size (p<0.01), a higher tumor grade (p<0.01), a higher rate of tumor invasion (p<0.05), and a higher pTNM stage (p<0.05).
CONCLUSION
High levels of CD24 expression in the membrane and cytoplasm were characteristic in colorectal cancer, and the cytoplasmic CD24 expression was correlated with several unfavorable clinical parameters.
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